Original Contribution In Utero Exposure to the Antiandrogen 1,1-Dichloro-2,2- bis(p-chlorophenyl)ethylene (DDE) in Relation to Anogenital Distance in Male Newborns from Chiapas, México
نویسندگان
چکیده
1 Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC. 2 Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC. 3 Center for Population Health Research, Instituto Nacional de Salud Pública, Cuernavaca, Morelos, México. 4 Toxicology Centre, National Institute of Public Health of Québec, Saint-Foy, Quebec, Canada. 5 National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC. 6 Present affiliation: Worldwide Safety Sciences, Pfizer Global Research and Development, Groton, CT.
منابع مشابه
In utero exposure to the antiandrogen 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) in relation to anogenital distance in male newborns from Chiapas, México.
The insecticide 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) is still used for disease control in some areas, resulting in high levels of human exposure. The main degradation product of DDT is 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE), an antiandrogen. In animal experiments, in utero exposure to DDE decreases anogenital distance in male offspring. In these models, anogenital dis...
متن کاملSPECIAL THEME: INTERGENERATIONAL INFLUENCES ON HEALTH Prenatal exposure to 1,1-dichloro-2,2-bis (p-chlorophenyl)ethylene (p,p0-DDE) in relation to child growth
The toxic effects in humans of DDT and its degradates, however, have not been adequately characterized. 4,5 Both DDT and its primary degradate, p,p0-DDE [1,1-dichloro-2,2-bis(pchlorophenyl) ethylene, hereafter DDE] are resistant to degradation and bioaccumulate in the food chain. Data from some studies suggest that perinatal exposure to certain organochlorine compounds may affect body size in c...
متن کاملThe environmental pollutant 1,1-dichloro-2,2-bis (p-chlorophenyl)ethylene induces rat hepatic cytochrome P450 2B and 3A expression through the constitutive androstane receptor and pregnane X receptor.
1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE), a persistent environmental contaminant, is a metabolite of the pesticide 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT). DDE is similar to phenobarbital (PB) in that both compounds are inducers of rat hepatic cytochrome P450 2B and 3A (CYP 2B and 3A). The induction of CYP 2B and 3A by PB is known to be regulated through the nuclear recept...
متن کاملNonoccupational determinants of plasma DDT and p,p'-DDE in men from Chiapas, Mexico.
A cross-sectional study was conducted to evaluate nonoccupational biological exposure to 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (DDT) compounds and to identify the main factors associated with such exposure in a malaria endemic region in Mexico. Capillary gas column chromatography was used to determine levels of p,p'-DDT and its metabolites in plasma. The mean age of the 144 male partici...
متن کاملMaternal serum level of 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene and risk of cryptorchidism, hypospadias, and polythelia among male offspring.
1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) is a metabolite of the insecticide 2,2-bis(p-chlorophenyl)-1,1,1-trichloroethane (DDT) and is a ubiquitous environmental contaminant. Nearly everyone in the United States has a detectable serum level of DDE. DDE was recently found to inhibit binding of androgen to its receptor and to block androgen action in rodents. Normal development of ...
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